While working as a health club masseuse, Kimble is recognized by Sheriff Bray, a local lawman with policial aspirations. But Kimble manages to escape with the help of co-worker Steve Edson. After confiding with Steve his secret, Kimble learns that Steve is a fugitive of conscience: five months earlier, Steve was tried and acquitted for the murder of his girlfriend Linda's abusive brother, a murder that Steve actually committed and he apparently cannot live with the guilt over having gotten away with it. Kimble reluctantly lets Steve travel with him. But Steve begins leaving behind clues that soon puts Sheriff Bray back on their trail, including contacting Linda for help and letting her vengeful other brother, Joey, track them down.

After finding refuge in an orphanage, Kimble becomes entwined in the plight of a troubled teenage boy who passes him off as his uncle.

While working as a hotel steward in Wyoming, Kimble is forced to run after learning that another hotel employee has stolen hotel funds, and Kimble becomes the suspect. Kimble escapes on a tour bus containing a bickering couple called the Langners, a visiting spinster named Louanne, a local guy named Sandy Baird, and the bus driver. But Kimble becomes trapped when the bus breaks down on a back road, and all the passengers discover his secret when his identity is revealed over the radio. Held at gunpoint, Kimble must find a way to escape by emotionally getting between his various captors before the bus driver returns with the police.

While traveling through an small Oklahoma town, Kimble is arrested, not because the police recognize him, but because they've mistaken him for Leonard Hull, a former numbers runner about to testify against a big-time racketeer, whom has run away from a witness relocation program in that very town. Kimble is taken to a motel where Leonard's wife, Mavis, knows he's not Leonard in which Kimble asks for her help to get away from the police, and a local hit man pursuing them.

Kimble's sister Donna summons him home with a possible break in the case: a letter from James Eckhardt, a former U.S. Army captain whom also saw the one-armed man fleeing from the Kimble's house on the night of Helen's murder. Kimble meets with Eckhardt who agrees to help the fugitive out. Eckhardt's story seems strong enough to clear Kimble. But unknown to either men, another witness comes forward: a convict in prison for drug dealing, who reveals that he used to sell heroin to Eckhart for a Korean War battle wound and that Eckhardt was on his way to see him that night to buy some drugs, which is more than enough for Gerard to discredit Eckhardt's testimony.

Ralph Schuyler is a government agent who goes undercover as a boat captain to spy on Felice Greer, the wife of an international embezzler hiding out in Mexico and she's presumably coming down to him with the stolen money. Kimble happens to be on the boat too as a hired deck hand. When Ralph learns that Kimble's identity is false, he takes Kimble's fingerprints and after an 'emergency' landing, the agent leaves the fingerprints with a local Mexican shopkeeper and notifies the authorities of Felice's whereabouts. But when Ralph is badly burned in a engine room fire, Kimble tries to save him and takes over the boat's steering to safely make it to their destination. But when Kimble intercepts a cable with the incriminating report on his fingerprints, Kimble is torn between fleeing or staying to help Ralph, while Kimble also discovers that Felice's husband is up to no good concerning the stolen money.