The evil, diminutive Dr. Loveless impoverishes an Indian tribe so that he can become their benefactor -- and their god.

The agents travel to Hayes City to identify the body of their archnemesis, Dr.Loveless. While there, they meet up with Miguelito's next of kin, Dr.Liebknicht, a Swiss neurologist. However, as they pursue the origin of a key found on the body, they find that Loveless is hardly dead and has plans to use his neurologist guise to give Jim a lobotomy!

While investigating why fishing had been prohibited on local waters, agents James West and Artemus Gordon are attacked by a rough bunch of sailors. After the melee, Lt. Bartlett, who was apparently the victim of some sort sea creature. West joins a resolute fisherman on his boat and are attacked by a giant squid. But things are not what they appear as an even more insidious threat is revealed.