James West is tried by a court of cutthroats who believe he has murdered his friend and fellow agent, Artemus Gordon.

James West and Artemus Gordon help evacuate the town of Tonka Flats before it is destroyed by a cannon shell. Afterwards, they are notified that a man identified as ""The Falcon"" has threatened to obliterate Denver unless the U.S. government pays him $1,000,000. ""The Falcon"" is also in cahoots with syndicate leaders from Turkey, Spain, Prussia and England. During their investigation, Gordon is threatened by a whip-wielding Spaniard named Munez who suspects Gordon knows too much about the top secret weapon. West rescues Gordon from Munez, who is then killed by an explosive meant for the two agents. While searching Munez's body, West and Gordon find an invitation from ""The Falcon"". Gordon, disguised as Munez, prepares to attend the meeting while West attempts to penetrate the stronghold where the cannon is housed.

The stress of Secret service work appears to be finally getting to Jim as his temper flares and he makes mistakes. As West is being recruited by some member of the underworld who seeks to capitalize on his misfortune,Artemus and Conel Richmond struggle to find out exactly who,for what,and why.

During Mardi Gras West is grabbed by Major Hazard: the leader of a gang of crippled Civil war soldiers seeking revenge on the camp's commandant, Mosely. Jim reluctantly agrees to help them, only to have Mosely taken from him by the soldiers. He tracks them to the abandoned camp, where it turns out that Hazard and his men aren't crippled. They were in league with Mosely, who stole a shipment of gold and hid it. Mosely double-crossed Hazard and his men, so now they want the gold. Thanks to a diversion by Artie (as a geologist who can find gold with a divining rod), Jim escapes and in the ensuing fight, Hazard is killed when the gold falls from its hiding place: the camp's water tower.

An escaped murderer plots a bizarre scheme against agent James West, the man who had imprisoned him several years earlier. Attacked and knocked unconscious, West awakens in a stange deserted town filled with assailants wearing masks in the likeness of Stark. Gordon searches for his lost partner and soon finds himself in a similar predicament. West and Gordon must avoid deception to find and take out the real Stark.

In the town of Epitaph, owned by Epitaph Mines, agents James West and Artemus Gordon arrest Norbert Plank, chief bookkeeper for the powerful syndicate that owns the mining company. Through Plank, the agents hope to get their hands on records that could build a case against the organization. The whole town turns out to free Plank, whom West has hidden in a church bell tower, while Gordon masquerades as lay-preacher Hallelujah Harry. Gordon hopes to get to the head of the syndicate, Diamond Dave Desmond, and walk off with the ledgers. But Diamond Dave's girlfriend, Rhoda, has the same idea and blackmail on her mind.

Agent West is summoned by a note from agent Gordon to the local barbershop. While waiting for Gordon, West decides to have a shave and is promptly anesthetised by a hot towel from one of Dr. Loveless's assistants, working in disguise. When he wakes up, he finds himself in a carnival funhouse where he encounters dazed-looking Justice Alonzo Fairlie. Before he can get any information from the judge, he is attacked by a quartet of gunmen. He quickly dispatches his adversaries but Justice Fairlie disappears in the confusion, leaving behined a strange clue.

Jim meets with crime czar Sabatini, who asks him to travel to Calliope, MO to protect a lady and give a man called Swanson a key. Accompanied by government chemist Ned Brown, Jim travels to Calliope (where an Army finance officer died after stealing half a mil). Swanson is killed and the lady turns out to be Sabatini's ward blind Sylvia. It turns out Sabatini was the officer and Sylvia was the daughter of Boorman, Sabatini's partner in the robbery. Dodging Boorman, Jim and Ned find Sabatini's deed leaving all of his property to Sylvia.

West meets up with Gordon, who has just arrived in New Orleans with a famous Italian diva and niece of the ambassador on his arm, an escort urged by President Grant. West agrees to substitute as the lady's guardian for her appearance that evening at the opera, but the performance is interrupted when Montebello's would-be kidnappers bring down the curtain and West jumps into the fray. Discovering that sereral divas had recently disappeared in New Orleans, the agents must rush to unravel a plot involving the secret Order of Lucia and reveal who among their new acquaintances is playing a role on and off the stage.

West deals with the kidnapping of the Governor's daughter while Gordon rushes to find Jim to inoculate him from the disease one of the criminals was carrying. The disease proves to be the turning point in the fight between the feds and the criminals as Gordon convinces the gang to turn themselves in exchange for the cure to the disease.