An automotive engineer who has been framed for murder is rescued from police custody by her husband; they flee to New Orleans, beginning a cross-country odyssey to avoid the law and the real killers.

Falsely convicted of murder, the fugitive Kate Wyler kidnaps Estelle Modrian the auto mogul who framed her, and tries to extract information in an abandoned warehouse.

Jim and Katy arrive to a small town and play as singles in order to ward off suspicions. Some townspeople are suddenly falling sick because of the water poisoned by the toxic waste dumped from the chemical plant where Katy is working.