New arrivals in Cardale as The Pullen family arrive to take over The Black Swan and Physio Kerri Davidson starts work at The Beeches. Meanwhile Joanna meets an old friend at a school reunion and Andrew solves Sam's housing situation.

Sam helps Rob come to terms with his parental responsibilities on the anniversary of Allie's death, whilst Kerri tries to persuade Andrew to keep an open mind about her alternative health remedies

A tough time for the Pullen family when Maisy is taken ill. Despite their support towards her recovery, Maisy confides in Joanna that she'd rather be dead. Will Joanna follow her heart or her head?

Kerri becomes increasingly jealous over Sam's budding relationship with Serena. Meanwhile Andrew becomes involved in the plight of Lucy Turner and finds himself growing fond of her mother Kate; wife of PCG chairman Richard Turner.

Joanna is drawn into an emotional minefield when one of her patients appears to have been mistreated by one of her G.P friends. Serena begins to show her possessive side and Joanna receives some big news.

Liz is shocked to find out she is pregnant, however as she and Mike begin to accept a new addition to their family, a twist of events leads them having to accept a loss. Meanwhile Sam breaks up with Serena and Andrew and Kate grow closer.

Alex is faced with a big decision when her husband arrives in Cardale looking for a reconciliation. Kate has to decide whether to stay with Richard for Lucy's sake or to make a life with Andrew for her own happiness. Meanwhile Julie Pullen learns a tough lesson in love.

The pressure from brewery is too much for Mike who discovers he has angina, however he doesn't take the illness as a warning sign and soon ends up in a worse state. Meanwhile Sam is not happy about the practice set up and Tom tells Alex Will's daughter has Cystic Fibrosis.

Andrew and Sam are forced to call on their medical expertise when a lorry carrying toxins crashes into The Black Swan, trapping themselves and many other Cardale residents. The situation brings feelings to the surface for Andrew and Kate and Sam and Serena. Meanwhile Joanna's secret is revealed.

The Beeches staff struggle to pick up the pieces after Joanna's tragic death. Andrew continues his dangerous liaison with Kate, Sam learns a secret about Kerri, whilst Tom has to decide whether there is a future from him in Cardale. Meanwhile new doctor Alex Redman makes a dramatic entrance.

A horrific car crash puts The Beeches on red alert and requires all hands on deck, however the case is closer to home when they find out Sam and Kerri are the victims of the accident. As the day goes on, events bring Tom and Alex closer, and there's a surprise visitor for Will.........

Nick risks his health to pursue his cycling career, whilst Sam gets himself into deeper trouble to pay for Kerri's physio and their impending wedding. Meanwhile Will and Kate clash when their personal problems begin to cloud their work judgement.

The situation between Tom and Alex comes to a head when Tom and Mark clash over a patient. As Sam and Kerri's wedding day approaches, Sam's secret is discovered. Will he stay in Cardale to face the music, and if he leaves will Kerri join him?

Will offers Kate a place to stay when her house is flooded. Being so close to her again makes Will realise that he is still in love with her - does Kate feel the same? Meanwhile Tom and Alex find it hard to keep professional differences separate from their private lives.

Will faces a tough time when his actions are blamed for a patients death. Alex fears she has the same illness that killed her mother, however as she refuses to let her friends help her, will she have to face the situation on her own?

As news of Alex's illness spreads, Tom finds it increasingly hard to convince her to follow her consultants advice. Will the pressure from friends and colleagues force her to seek solace elsewhere? Meanwhile there's good news for the Pullens when a family treasure brings a little more than luck.

Tom travels to York to find Alex. However she continues to push him away and forces him back to Cardale. The Pullens make a decision about the pub and their future, whilst Will and Kate work hard to stop their jobs interfering with their relationship. Can Will and Kate get over another hurdle and will Alex return to face her illness and Tom?