In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to HYDRA once and for all. Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D.?

Coulson and General Talbot are forced to team up and attend a worldwide symposium on Inhumans, where they suspect Malick has an inside man. As the S.H.I.E.L.D. team gets closer to the truth, an unexpected traitor is revealed.

Agent Daisy Johnson must call upon the Secret Warriors for an inaugural mission that will leave no member unscathed, and S.H.I.E.L.D. learns more about Hive's powers, forcing them to question everyone they trust.