Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.

With the loss of half the team, the remaining members search for answers as the clock counts down for Ghost Rider.

S.H.I.E.L.D. and Ghost Rider find themselves unlikely allies when the lives of all of Los Angeles hang in the balance.

Coulson is unaware of a dark secret May is hiding, even as the two grow closer; Aida is determined to find the Darkhold.