西雅图被雾气笼罩，杰克森神秘消失，欧文和克拉席展现他们对泰蒂的爱，德鲁卡为梅若迪丝打掩护。

当杰克逊邀请新女友Vic参加他认为是Richard和Catherine的周年庆祝活动时，却发现晚宴是因为不同的原因而举行的，这让他陷入了一种不舒服的境地。在其他地方，Levi带着Nico去看望一位生病的家庭成员。

It's Thanksgiving, and while Meredith faces travel complications due to the weather, Nick steps in to help in more ways than one; Richard and Bailey seek out emergency surgeries; Amelia and Link reconnect.

Bailey is on edge when an accreditation council stops by Grey Sloan to review the residency program, while Richard sets an assessment of his own for the same day. Meanwhile, Nick returns to Seattle to perform a first-of-its-kind operation with Meredith.