A hacker compromises the hospital’s computer system, causing monitors, phones, labs and patient files to all go down. As technology fails them, Bailey attempts to keep the peace but chaos erupts and the doctors are forced to get creative in their methods to treat the patients.

Jo finalmente enfrenta seu marido abusivo, enquanto Gray Sloan continua trabalhando com o FBI depois que o sistema de computador do hospital é comprometido por um hacker.