Dopo Brian Mobley, che più volte si è rivelato una spina nel fianco per Grissom, ecco arrivare Rory Atwater, il nuovo sceriffo di Las Vegas. Anche lui darà filo da torcere alla squadra CSI in relazione ad una irregolarità che rischia di mettere la polizia in cattiva luce. Tutto nasce da un coltello trovato da Warrick nella macchina di un sospettato. Il problema è che il mandato copriva solo la scena del crimine, ma non l'auto. Ciò rende la prova inammissibile. Grissom e gli altri dovranno così ricominciare tutto da capo, e avranno solo 24 ore per trovare nuove prove prima che il presunto killer venga rilasciato.

A woman is found dead in a hotel suite with symptoms of the ebola virus. Another woman is found dead with similar symptoms. Catherine and Nick investigate. Sara and Greg with help from Grissom try to determine how a the owner of a home was killed. His home was tented for infestation.

A serial killer strikes again, and the CSI team tries new technology using evidence from a prior killing. They find a fingerprint belonging to Jesse Acheson, who becomes the prime suspect. A boy confesses to the killing of his brother, but evidence suggests that he may not have committed the crime.

A man (Alan Rosenberg) whom Catherine flirted with at a bar reappears in her life as a suspect in a murder investigation.

A 28 year-old single mother is found dead. Initially, it's believed to be a suicide, but Catherine determines she was murdered. Also, Ecklie summons Grissom to refute the testimony of an entomologist in a murder trial.

The CSI's are called out to investigate the disappearance of a boy whose father died four years ago. Soon a couple is arrested at a convenience store with a boy matching the description of the missing kid. The only problem is they both claim it is their son. Both parents have exactly the same picture of the boy, with a scar on exactly the same place on his face. They hope a DNA-test could confirm who the real parents are, but when this information comes to light, it lead to another bizarre twist, possibly murder.

The CSIs become the focus of a reality TV series, which follows them while they investigate a serial rapist, who recently gained access to a woman's apartment by posing as a fireman. Also, Warrick's work on the late-shift is causing problems with his marriage to Tina.

Sara questions her future as a CSI when a past case comes back to haunt her, the 12 year old Hannah, who has to back up her brother one more time with all new tricks up her sleeves.

Catherine comforts Warrick when he is accused of murdering a famous Vegas gangster and even he is uncertain of his guilt or innocence.

A hypnotist bank robber becomes the prime suspect in a murder investigation.

The team has a hard time investigating a shooting in Koreatown when none of the witnesses will talk about the crime.

When the team discovers a connection between a new murder and a serial killer, Grissom secretly joins the class of a criminal pathologist (Laurence Fishburne) to help crack the case.

The CSI team is shocked and saddened when, after working with Dr. Raymond Langston (Fishburne) on the "Dick & Jane" murders, Grissom announces that his time as a CSI has come to an end and offers Langston a permanent position on the CSI team.

The first day on the job for Dr. Langston turns from bad to worse when a simple burglary case quickly overlaps with a complicated arson and homicide case.

When a seasoned sky diver is paralyzed after free falling to earth when his parachute doesn't deploy, he turns out to be linked to the strange death-by-airborne-toxins of two wealthy men with ties to Iran.

A rising young star is killed in a wreck and her determined stalker claims credit, but the team finds out there's more to this tragedy than meets the eye.

The son of a notorious killer is arrested on suspicion of murder, and the CSI team must overcome their natural prejudices against the boy's antecedents in order to track the true culprit.

The team investigates the murder of Jason, a troubled computer geek working at a low-level casino support industry job who lures a colleague, Paulie, into a dangerous plan to make a working stiff's dream come true.

When a band member of Rascal Flatts is electrocuted by his own guitar during a concert, the CSI team investigates if it was a case of foul play.

When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.

A legendary comic from the good old days of Las Vegas is set to reunite with his partner on stage for one night only, until one half of the famous duo is found dead.

The CSI team investigates a well-orchestrated bombing at the funeral of Officer Franklin Clark

The CSI team investigates a mad slasher who strikes without leaving a trace -- because he wears a form-fitting black latex suit that leaves not a molecule of evidence behind

The CSI team investigate a murder at the home of Marta, a "level 5 hoarder" whose home is stacked high with possessions and garbage--and more than one dead body

The CSIs set out to track down a pedophile suspected of murdering an FBI agent's wife and kidnapping his children.

Following his escape, Nate Haskell, the notorious "Dick & Jane" killer, resurfaces when he e-mails a disturbing video to the father of one of his brides, threatening to take her life.

After years of pursuit and a countless number of murders, Langston comes face-to-face with serial killer Nate Haskell inside the house where his killing spree began.

The CSI team says goodbye to Catherine Willows as she makes a life-changing decision.

When a house is stolen completely off its foundation, the CSIs are on the case in search of answers. Meanwhile, new CSI Julie Finlay showcases her skill in blood analysis.

The CSIs arrive at their favorite diner only to discover a gruesome crime scene with eight dead victims and a lot of questions

The CSIs need to ace the case involving a rising tennis star. Meanwhile, the CSIs are surprised to hear Hodges is engaged to an Italian bombshell.

Sara is a lead suspect in an investigation after a brief encounter with another man in which she was the last person to see him alive. Also, her separation from Grissom begins to take a toll.

La squadra della scientifica di CSI è chiamata a indagare su un omicidio ed una rapina, avvenuti a una partita di poker che ha avuto più di un milione di dollari in fiches sul tavolo e che hanno fatto gola a qualcuno che non si è fatto scrupoli nel volersene appropriare

Un senzatetto viene trovato morto in un vicolo. L'indagine della squadra li porterà nel mondo dei casinò e nel sottobosco dei banchi di pegno.

Una coppia viene selvaggiamente accoltellata in un motel. La squadra di Russell avvia l'indagine, collegando il caso con altri due simili, avvenuti sempre nella stessa squallida stanza dello stesso squallido motel.

La squadra investiga sull'omicidio della ricchissima moglie del proprietario di un casinò: le caratteristiche del delitto spingono gli uomini a lavorare con la Divisione Crimini Cibernetici dell'FBI. Back-door Pilot CSI: CYBER

Il team è chiamato ad indagare su un caso che si ricollega ad un omicidio avvenuto 25 anni prima e mai chiarito del tutto. Intanto la figlia di Brass viene ricoverata in ospedale, vittima di overdose.

The CSI team take a look into the death of a woman who has been drinking and taking drugs in a pool at a rehab facility.

The CSI team reopens a 10-year-old murder/suicide case when the sole survivor claims her accused father was innocent.