A bomb goes off in an office building killing one and injuring many more. The chief suspect is a security guard who left minutes before the explosion and has knowledge in bomb making. Nick helps his prostitute friend again. After giving in to his passion, she is found dead the next morning. Naturally, Nick is a suspect and to make it worse, Ecklie has the case.

When a single human bone is discovered in the desert, Grissom and Catherine must cover miles of territory to find the rest of the skeleton. And Warrick and Sarah trace the death of a male stripper to members of a wedding party who may have celebrated a little too hard the night before the nuptials.

A woman is abducted from a mall parking garage. She's raped, beaten, shot and left for dead. Sara collects evidence from her and grows attached to her. Nick and Grissom analyze the crime scene. Catherine and Warrick are given boxes of evidence from a shooting that goes to trial in four days. The CSI who had the case has quit and they have to prove what happened. To make Catherine's life more complicated, Eddie has taken out a second mortgage without her knowledge.

Grissom and Sara are called to the crime scene when two murder victims are found hidden in pipes at a construction site in the middle of an alfalfa field, while Catherine and Nick investigate an ostensible hunting accident.

Distracted by an attractive passenger, an Indian taxi driver feels his cab strike something at a suburban intersection. When he gets out to check, he finds a teenage boy pinned beneath the left rear tire, apparently killed on impact. The cabbie jumps back into the taxi to call for help, but a mob of angry onlookers - all of them white - drags him out and beats him for the crime. When Grissom arrives on the scene, he discovers that the teen has been eviscerated and has stab wounds, but shows no signs of having been struck by the cab.

Warrick investigates the drive by murder of a young girl in his old neighborhood. The girl's father is a friend and mentor of Warrick's as well. Warrick struggles to control his emotions to the point where Grissom pulls him off of the case. Nick tackles the murder of a computer company employee. The only supects are the three other employees in the building.

Warrick's appearance at the preliminary hearing on a rape and murder case goes terribly wrong when the only piece of evidence is thrown out on a technicality. Grissom and the team have 24 hours to make the case with new evidence or the killer will go free.

A roller coaster runs off track leaving 6 people dead. The CSI team must uncover whether this was an accident, or foul play. Warrick and Catherine try to find the killer of a 13 year old girl.

Grissom is confronted with new evidence while on the stand of a murder trial of a restaurant owner. This development requires the reopening of the case and Eckley initiates an inquiry into Grissom and his team. The results of the inquiry lead to dramatic changes of the CSI team and the series.

Grissom and his team investigate the starving death of a five year old boy. They discover the boy has siblings who are in danger too. Catherine and her team determine who killed a prisoner in a holding cell brawl.

Grissom, Sofia, Sara and Greg investigate the disappearance of a woman coming home from a night out with a friend, her abandoned car found on the edge of a highway. Catherine, Warrick and Nick investigate the deaths of a hunter and his prey, a Kodiak bear.

The CSI team investigates the murder of a man suffering from a congenital hypertrichosis, causing him to grow excessive body hair. Elements of the case suggest a connection with a belief in werewolves. The case leads to the victim's sister, who suffers from the same disease. Because of her condition, she'd been hiding from the world, but it turns out that she's hiding facts that are vital to solving the case.

Grissom attempts to get a confession from a neighborhood pedophile by having him help in locating two missing boys. The sex offender is the main suspect. The investigation is more complex than the team ever thought it would be.