A body is found in a pottery store in what's apparently a robbery that was interrupted. Fingerprints at the scene seem to match a twenty year old kidnapping case. Sara and Warrick look into a case where a woman burned to death in her home. The woman was burned to an ash but only the chair she was in was burned, the rest of the house is fine. Sara believes they have a case of spontaneous combustion.

Two women run over a deaf man but they didn't kill him- he was already dead. Grissom has to find out who did it and he's not getting help from the deaf man's school. Catherine and Nick investigate an apparent mob hit that leaves five dead in a coffee shop.

Grissom and his team investigate a casino heist during which innocent victims were shot, while Catherine and Sara are called to the scene of a murder in a remote part of the desert.

Grissom and Catherine investigate the murder of a despised comic who died onstage, apparently after drinking from a tainted bottle of water. The case grows more puzzling when a 15-year-old boy dies in a convenience store after drinking the same brand of water. Brass reopens a woman's accidental-death case after spotting the deceased's husband in a flashy new car with a trophy date on his arm.

Quando un'autobomba uccide tre persone davanti a un casinò, lo sceriffo di Las Vegas Rory Atwater, vera spina nel fianco dell'unità CSI, sospetta immediatamente che si tratti di un feroce atto terroristico. Grissom è però di un altro avviso, e intende dimostrare che dietro la strage si nasconde un altro movente. Intanto, Sara e Warrick hanno il compito di scoprire chi ha ucciso la moglie di un noto cantante di Las Vegas.