A wild night in Las Vegas has the CSIs simultaneously investigating four fatalities. Greg Sanders' first day in the field has him assisting Grissom's investigation of a fatal nightclub shooting. Meanwhile, Catherine probes into the death of a stripper found dead in a hotel room, while Sara and Nick look into the strange case of an "alien" body found near Area 51.

The investigation into a body found in a chimney leads the CSIs to re-open an investigation of an unsolved homicide of a female teenager named Caroline Fitzgibbons.