Once he unseals a package sent to him through the mail, Grissom is floored when he finds a miniature crime scene inside. The finding is entirely more perplexing since the successive killer accountable for earlier related miniature crimes is now deceased. Grissom plows to examine the miniature and discover the actual location, when the investigation makes it clear the murder showed has yet to happen, but is probably going to happen soon.

Grissom and his team are discouraged when they find a pool of blood as they begin investigating the disappearance of a high school basketball star and his cheerleader girlfriend.Grissom's quip that the young lovers may have run off to Mexico is soon quashed by the discovery of drops of blood by Ryan's vacant parking spot at the school. After finding a letterman jacket and cheerleading sweater in the field house and a pool of Ryan's blood nearby, the team tries to determine what went awry.

The terrified eyes and cryptic words of a murder victim haunt Sara while she processes the house where several showgirls were killed.

After a man is killed in his limousine, Greg finds that the murder victim has ties to the man he had to kill in self-defense. The team finds that the brother is involved in this investigation and has to deal with him and his hostile mother.

The CSI labrats take center stage to discuss the case of the Miniature Killer.