Stan Smith is mad because after getting his wife a job (or "hobby") as a Real Estate agent, she makes more money than him. In the meantime, his daughter Hayley ran a program that helped the homeless, and Stan's son Steve had an idea to have a Bum Fight program. To get back and to try to gain more money than his wife, Stan takes Steve's idea and starts a Bum Fight Night where he takes bets and treats the homeless like wrestlers. But with the homeless petition, Stan has to end up fighting like a homeless man himself.

When Stan forgets his anniversary, he arranges to have 20 hours of Francine's memory erased, but the CIA temp on duty accidentally erases 20 years. Francine, having reverted to her wild child days, moves into her old apartment with Hayley as a roommate, and ends up going to a festival with Hayley's boyfriend. Meanwhile, Steve asks a good-looking girl out, but needs his wingman, Roger, to "jump on a grenade" for him and date her ugly cousin.

Stan finds Deputy Director Bullock, his supervisor, starting a relationship with Hayley. However, he can't risk saying or doing anything about it because he's up for a promotion at the CIA. Meanwhile, Steve finds Dick Cheney's BlackBerry and uses the contact numbers to play pranks on political figures from around the world.

As Stan continues to dominate the household, Francine finds herself idolizing a group of women who seem to have it all. She tries to impress them and even lies in order to gain acceptance into their group, until she realizes they aren't as perfect as they seem. Meanwhile, loyalties are tested when Stan gets a new best friend.

When Francine's birthday brings back haunting memories of a celebrity film moment stolen by George Clooney, Francine's new dream is to destroy the star. But when she tries to win Clooney's heart with the intention of breaking it, Stan actually falls for him and sabotages the plan. Meanwhile, back at home, Roger builds a vineyard and starts up a private sweat shop of foster children.

Stan has his heart set on speaking at the Republican National Convention on behalf of the Langley chapter, but when they pass him up for another candidate, he accepts the only endorsement he gets from the local chapter of Gay Republicans. While the people around him disapprove of his new lifestyle choice, Stan decides to follow his heart to speak on their behalf.

While researching a paper about George Washington Carver in celebration of Black History Month, Steve uncovers a conspiracy that's been going on since the Civil War. When the curator of the Smithsonian Peanut Museum reaches out to tell Steve the truth, he's mysteriously murdered, and Steve and Stan are tracked by a secret society that will stop at nothing to keep this scandalous secret of American history.

Stan, who had Hayley brainwashed because he wanted her to be a sleeper CIA agent, activates her and orders her to marry a senator's son. Meanwhile, Roger and Steve decide to open a detective agency like the ones in the '70s TV shows they have been watching.

After outing himself as an alien, Roger (in disguise) finagles his way into being appointed the CIA's chief alien hunter to take advantage of a lavish expense account--while coming up just short in attempts to catch himself. Meanwhile, Francine shocks her family by displaying a prejudice they never knew she had.

Stan emcees a CIA telethon to raise funds for the agency's torture budget after Congress slashed it. But Roger is out to sabotage it because Stan stole the idea for it from him.

Steve and his friends sabotage a stuck-up kid's bar mitzvah after the kid hits on Steve's girlfriend, Debbie. But when Snot is wrongly accused of stealing the kid's bar-mitzvah money, his own bar mitzvah is put in jeopardy.

Steve is left home as the family plan a trip to Boston hoping to locate a college for Hayley. When his friends arrive they convince him to break the rules, resulting in them finding the controls to a military drone in Stan's study.

Meanwhile, after Stan leaves the plane to return home for his painkillers, Roger changes disguise from a little girl to a Stan constume so he can get served alcohol. When an air marshal notices that the girl is missing, he grounds the plane and investigates.