Chevy Chase and Dan Aykroyd move to Quahog. Brian and Stewie find out about their secret agency. They are told that there are Russian Sleeper Cells all over US. They go talk to Mayor West, and find out he is one of the sleeper cells. They follow Mayor West to Russia where they disable a nuke aimed at the US.

Brian decides to confront Rush Limbaugh when he comes to Quahog for a book signing.

De nieuwe vriend van Stewie krijgt een ernstige, maar behandelbare ziekte. De ouders van de jongen weigeren de behandeling vanwege hun religieuze opvattingen.

FAMILY GUY is reimagined as a series that’s been on the air for 60 years and, in a special retrospective, it looks back at the cultural events and issues that were tackled on the show in the 1950s, '60s and '70s.