With Sharona in New Jersey to visit her ailing mother, Monk is left in the very incompetent hands of his annoying upstairs neighbor, Kevin Dorfman, but the prospect of a week with Kevin is eased somewhat by a visit from Trudy's father, Dwight Ellison. Dwight invites Monk (and Kevin) to spend the week with him and his wife, Marcia – and at the same time investigate gameshow host Roddy Lankman, who appears to be involved in a conspiracy to allow one of his contestants, Val Birch, to win every game. Despite the memories of Trudy aroused by spending time with her parents in her former home and the questionable help of Kevin, Monk discovers evidence that Lankman visited Birch's house – and that Birch visited the site of the accident that killed Lankman's assistant, Lizzie Talvo. To discover exactly how Lankman and his crooked contestant are communicating – and possibly prove that they're involved in something much worse than cheating – Monk becomes a contestant on the game show. His knowledge o

Captain Stottlemeyer and Lieutenant Disher are making a routine arrest when a mysterious man in a car drives up and shoots at them, wounding Stottlemeyer. When Monk and Disher try to apprehend their prime suspect, Monk’s obsessive-compulsive disorder allows the suspect to escape. Consumed with guilt, Monk goes to Dr. Kroger who gives him a drug to alleviate his obsessive-compulsiveness but impairs his sleuthing ability.

When John Ricca, author of a controversial and unfavorable biography of martial artist Sonny (""the Cobra"") Chow, is found dead in his home, all the evidence points to Chow as the murderer. Unfortunately for Captain Stottlemeyer, his chief suspect has been dead for six years. While Monk and Natalie (who's more interested in being reimbursed for her business expenses than in solving the case) visit Chow's former teacher, Master Zee, who claims that Chow died in his arms, Stottlemeyer resorts to having the corpse dug up to prove that, despite rumors to the contrary, Chow is indeed dead. A dental X-ray proving that the corpse is Chow leaves Monk to figure out who tried to frame the dead man for murder. On an inadvertent tip from Disher, an avid Cobra fan, Monk and Natalie visit the Sonny Chow museum, where Monk finds two important clues--a hairbrush that has been stolen from its case and replaced with a lookalike and the stamp that the museum proprietor placed on Natalie's hand so that she

Monk goes toe to toe with a popular radio shock jock who is suspected of killing his wife.

Monk is arrested for murder, and finds that he has to go on the lam to clear himself.

Stottlemeyer must keep up the pretense that Monk is dead, while Adrian tries to determine who framed him for murder.

As Monk and his friends watch a TV news magazine piece on the solution of his hundredth case, he realizes that one of the victims was murdered by a different killer.

Monk is called to a murder at the location where he first heard of his wife's murder, and while Monk figures out who the assassin is, he doesn't know that the one who ordered the hit is also responsible for the death of Trudy. Knowing that Monk will eventually put all the pieces together, he orders Monk's death, and when all hope seems lost, Monk discovers something which could finally end his 12-year nightmare.

After listening to Trudy's last message, Monk finally discovers who killed his wife. Racing against time before he dies of poison, he must make a fateful decision.