A creature named Annihlus appears in Reed's lab, soon followed by his mortal enemy, Blaastar. The Fantastic Four learn these two enemies come from the Negative Zone and must return them before it's too late.

A nuclear explosion caused by Doctor Doom causes the Fantastic Four to lose their powers. Reed's efforts to restore their powers is cut short after Doom takes over the Baxter Building. The team will need the help of Daredevil to retake the Baxter Building and get their powers back.

Gorgon is searching for Medusa to return her to the mysterious Great Refuge. Johnny is forced to help her, but Gorgon captures her. The Fantastic Four discover his hideout and find the Inhumans.

The Inhumans teleport back to the Great Refuge, but Johnny is teleported there too after jumping in after Crystal. The rest of the team try to find him, while it is learned Black Bolt's evil brother, Maximus, has taken over.

Sue insists the team get some R, but Johnny stays at home. The others head to Tee Vu island, which is home to a Kree Sentry. Meanwhile, Black Bolt destroys the negative barrier and frees the Inhumans, reuniting Johnny and Crystal.