Sam and Brooke wager on whether or not Sam can land a boyfriend by the end of the week and whether Brooke can prove that her relationship with Josh is more than just physical, with the loser publicly joining an embarrassing club. Meanwhile, Lily hands out condoms to her classmates in response to the popularity of a new singer whose sexual image is mimicked by some students at Kennedy High.

Principal Hall forces Josh, Harrison and Sugar Daddy to attend a weekend sensitivity camp after they harass a scantily clad Lily. Sam and Brooke work on the school's crisis hot line and inadvertently heighten one of the caller's problems.

Sam runs away from home and hunts for Brooke's mother, with the hope that the woman will help her put an end to Mike and Jane's wedding plans. Meanwhile, Josh, Sugar Daddy, Harrison and Emory Dick go to a strip club with fake IDs.

Bobbi Glass (with her new nickname, Claws) has a new experiment for the students: they have to take care of baby dolls as if they were real babies. Everybody gets one, except for Lily who shares the doll with Carm. Because they don't know the baby's gender, they name it Hillary Swank - neither a boy nor a girl. Brooke is too busy because she is moving to San Francisco with her mom, and doesn't have time to take care of the doll. Emory's twin sisters, Emma and Emily (Em&Em, a parody of the rap singer Eminem) come to K. High looking for lessons from Nic and MC for how to become popular. Too busy teaching the girls and organizing a party that will define popularity, they handle their babies to a British nanny, who eventually abuses them. Carm, concerned about the unpopular group, decides to help them, but neglects her baby. The twins become too powerful and turn against their teachers. Nic and Mary Cherry decide it's time to stop them and put things back on track. Meanwhile, Sam decides t

Harrison reveals that he has been taking medicine for bad headaches, which later turns out to be leukemia. Harrison is forced to withdraw from the campaign and Brooke wins. Sam realizes what she is doing and quits from Homecoming Queen election. Nicole, Mary Cherry and Hellacious team up to beat Carmen in the election and prove that there is no place for her. Reaching as low as publicizing Carm's mom's alcoholism and make her look as an alcoholic teenager. Carmen moves back to her mom's to support her and wins the election. Hellacious tries to cheat, but Principal Krupps busts her. Ms. Glass has her comeback and helps taking all her pictures off the girl's room homecoming queen hall of fame. Lily turns herself in to save Josh, but they are a couple now, and he decides to get punished with her.

After Harrison returns to school since he had his bone marrow transplant, he acts in a weird way, making everybody think he's possessed or something. The girls think about it and conclude that he has impersonated Nicole's personality, since she was the donor. They decide to call a priest to exorcise him. Meanwhile, Josh and Lily's relationship is growing so much that there's hardly any space left for Sugar Daddy in Josh's life. Feeling neglected, he finds a new friendship in George. They enjoy each other for a while until George feels like Sugar is demanding too much attention. Josh and Sugar make up. Nicole finds out she's adopted after she asks her mom about her birth and she doesn't give clear information. Shocked, Nicole finds out that her mom was a 16 year old cheerleader, and tries to find her with no luck. Both Nicole and Harrison conclude they have to find themselves.

Nicole's mom is not so happy about her spending time with her birth mom. Judy Julian tries to bribe Nicole's mom so she would disappear. Shaggy leaves and Nicole and Judy become closer. Meanwhile, the girls are bored with the immature behavior of the boys and their boring lives as high school students. Brooke meets a college girl who invites them to a college party. Sam and Lily are stuck at home for lying about where they where going and spend up playing board games with Sam's parents all night. Carmem meets a boy and goes up to his room. Feeling that something might happen, she hides inside the closet until the boys come to rescue her. After their experience at the frat party, the group learns that high school isn't so bad after all.

Sam and Brooke have a quick but intense argument over what each one has done to/with Harrison. Sam does not forgive Brooke for having slept with him, and Brooke puts Sam against the wall saying Sam turned him down so there were no strings attached. They both realize none of them is really wrong, and if there's anyone wrong there it's Harrison. At school, they give him the cold shoulder and George does the same to Sam. Sam and Brooke plan to stood up Harrison at a restaurant, but Brooke shows up and is caught by Sam talking to Harrison, which leads into a huge food fight. At home, Jane is trying to fix things between the two of them when her water breaks. Josh's mom announces she is moving away, and Josh has to either come with her or go live with his dad - which he does in order not to leave Lily. She suggests they get married, and although his mom tried to warn him that he was too young, he goes ahead and gets married to Lily right before prom. Mary Cherry accidentally bumps into Big