When famed neurosurgeon Dr. Ginsberg and her team pay a visit to St. Ambrose to save the life of Kayla, Addison is shocked to see Amelia Shepherd - Derek's younger sister on the team. But Amelia's presence causes strife between Addison, Sam and Pete when she claims she can save Kayla's life after Dr. Ginsberg declares nothing can be done. Meanwhile Charlotte seeks from Cooper's with a sex education seminar for the elderly that only leads to more tension between the two, as they try to figure out how to work together.

After Violet files for joint custody of Lucas, an embittered Pete voraciously fights back by hiring a tough attorney for the trial, forcing their fellow friends and co-workers to choose sides and have their personal lives dragged onto the stand and into the public eye.