Ed and Al become interested in biological transmutation after witnessing a chimera in Lior, so Colonel Mustang introduces them to an expert in the field, Shou Tucker, the Life-binding Alchemist. Meanwhile, a serial killer whose targets are only State Alchemists is on the loose in Central.

The battle for a nation's soul descends into chaos. Bradley unleashes death on those who dare engage him. Beneath Central, the one responsible for the Fuhrer's creation unleashes something far, far worse.