When an unidentified young girl is found murdered at a debutante ball, Danny and Jackie look to the prostitute found giving her a hard time on the hotel's surveillance camera for clues. Meanwhile, Nicky gets a glimpse of her first murder victim as she rides along with Danny when he gets the call to investigate.

Jackie goes undercover as an escort when she and Danny track down a serial killer who is murdering prostitutes in hotel rooms. Meanwhile, Erin meets a potential suitor at an art gallery who shares her interests.

When a rich woman dies of a heart attack, her eccentric daughter claims that she received a message from God, who told her that her stepfather actually murdered her. Meanwhile, the archbishop wants Frank's support for the canonization of a local priest, but a reluctant Frank takes it upon himself to investigate a rumor that the priest went too far when protesting the Vietnam War.

Danny and Jackie investigate the suspicious murder of a high rolling investor, who had injuries from a fight, but no marks on his hands. Meanwhile, Frank puts Jamie under house arrest, when the Sanfino family put out a hit on "Jimmy Reardon".