Danny and Baez investigate a murder attempt against a celebrated fertility doctor with a seemingly pristine reputation. Eddie must intervene in a Reagan family matter involving Danny's boys. Erin helps Anthony find justice after a date goes wrong.

Frank takes one of Jamie’s cases to heart when it involves the suspicious death of his friend’s, FBI Agent Wilson Ortega’s, terminally ill wife. Also, after demanding more meaningful cases, Erin receives an unsolved robbery case that proves to be impossible to crack without help from Anthony, and Danny and Baez uncover the shocking truth behind a puzzling assault claim.

Frank and Garrett quarrel when Garrett refuses to walk back a quote he provided to a local newspaper. Also, Danny and Baez discover a connection to a feud between local residents and city-sponsored hotels for the homeless while investigating a murder, Anthony is mistaken for a mafioso and Eddie pressures Jamie to take a love language quiz.

Frank must decide between remaining police commissioner and pursuing a new professional chapter when his old friend presents him with an exciting job offer. Danny and Baez investigate the murder of a restaurant delivery man.

An illegal drug shipment arriving in New York City must be found before the narcotics flood the streets; Jamie helps a neighbor handle a gambling debt; Frank receives pushback from Mayor Chase over his handling of a brawl.

Frank is at odds with his friend Archbishop Kearns when he says the NYPD arrested the wrong man for a murder; Eddie tries to get justice for a sexual assault survivor; Jamie and his nephew, Joe Hill, butt heads over fair police practices.

Danny and Baez investigate after a vicious attack leaves their mutual friend, Maggie Gibson, hospitalized; Frank and the team debate the appropriate memorial protocol for a former police commissioner with a questionable professional legacy.

Danny crosses paths with a criminal from a previous case when he investigates a gang attack with a shocking motive; Frank and Mayor Chase butt heads over an off-duty cop who goes too far making a political statement.

Danny and Baez’s investigation into the death of a chess hustler is complicated by interference from the victim’s son; Jamie tries to make amends with a man he regrets putting away as a young officer.

Danny and Baez race against the clock to catch a serial killer targeting young women; Erin and Eddie clash when Eddie intervenes in a murder case and Erin's personal life; Frank must decide how to discipline his grandson.

Frank clashes with the team when one of the members becomes the focus of a departmental investigation; Jamie and Danny team up to investigate a series of carjackings involving one of Danny's criminal informants.