The Spindrift crashes on the Land of the Giants and its crew and passengers quickly find themselves in a struggle for survival.

The Spindrift crew find an amnesiac Earthling, Joe, but it turns out to be a ploy by giant crooks to get hold of the ship's power supply.

A giant escaping convict takes the Spindrift but then wanders into quicksand, endangering everyone.

When the giants increase their search efforts, the Earthlings must increase their salvage efforts and end up captured by a giant and his daughter.

The Earthlings become involved with an insane giant scientist who has infra-red goggles he can use to find them whenever he wants.

The Spindrift crew must deal with the head of Police Security, who is attempting to undermine a Senator who believes in their cause and frame the Earthlings for sabotage.