A mass breakout occurs at each of the four supervillain prisons.

Ant-Man/Giant-Man, Hulk, Iron Man, Thor and Wasp band together to battle Graviton after he escapes from the Raft and targets Nick Fury.

When the Leader creates a bubble of gamma radiation emanating from the Cube that mutates any human it touches, the Avengers team up with Doc Sampson to stop him. Meanwhile, Hawkeye infiltrates a Hydra base in order to capture Black Widow.