Somewhere after those first heady days in the Garden of Eden, mankind jumped onto a slippery slope of bad behavior, making one wrong moral choice after another. Small wonder, then, that God's disappointed and considering destroying the whole thing. But he has a soft spot for his failed experiment and decides to give it one last shot: If he can find one person to convince him the universe is worth saving, he will. Just like that. And being a sporting deity, he lets the Devil chose, and so he does: Bob Alman, an autoworker whose goal in life seems to be to just sliding through. And never has there been a more unlikely, or more reluctant, person for the job. Fear convinces Bob to accept the mission, but God's vague instructions are no help. And the Devil, who figures he only has one soul to focus on now, is a formidable obstacle. On the job or at home with his family, Bob is forever changed. How can you watch a hockey game when the fate of the world is in your hands?

Bob doesn't take the Devil seriously, so to get back at Bob, the devil poses as a teenager and begins to court Bob's daughter Megan.

After God forgets the Devil's birthday, the Devil decides to go back to hell and take all the world's evil to show God how much he really needs him. Up in the world, Bob is realizing how everyone is much too nice, which eventually gets on Bob's nerves. So, he launches on a quest to reunite God and the Devil as friends so the Devil returns the world's evil.

God is disgusted with how much sex is shown on television and he decides to get Bob to go to Hollywood to get them to limit the amount of sex that can be on television. Bob is reluctant, but he soon comes to his senses when he realizes Andy has seen something he shouldn't, but will he be capable of opposing one of the most powerful people in the world alone?

Bob's father is dying though he doesn't care because his father was always abusive during his life. However, Bob cannot help but wonder if he will go to heaven or hell after he perishes, which causes Bob to go on a journey that may help him understand more about his father than he ever thought he would know.