When a tell-all book is published about Mackenzie Allen that contains confidential information suspicions arise. Meanwhile, the confirmation hearings for Vice Presidential nominee Warren Keaton begin, but raise questions about his past.

While Mac is busy working on her first State of the Union address, Rod becomes a tad tipsy and is found in compromising position with an intern for all the world to see. Meanwhile, Templeton sets out to find a way to sabotage Mac's Homeless Initiative Bill. Plus, Dickie and Jayne, who has gone back to being Templeton's chief-of-staff, go out on a dinner date.

Mac suffers a burst appendix while aboard Air Force One. Since there is no Vice President in place, Templeton becomes acting President since he is the Speaker of the House and next in line. Meanwhile, there is an air strike that is crippling travel on Memorial Day weekend and Templeton ends up overstepping his bounds and handles the situation the way he wants to.