Perry drives to the scene of a shooting and finds the police recovering the body of Harry Merrill from a car that went over the side of a mountain. MerriIl has a bullet in his body and a pillowcase over his head. Meanwhile, Perry's client, Evelyn Bagby, claims she was chased by a hooded man in a car near the same cliff that day. She fired two shots at the man's car to scare him off, and now the police want her for murder.

Fran Celane feels her uncle, Edward Norton, is too restrictive as the executor of her father's spendthrift trust. He also wants her to wait 18 months until her 25th birthday before she gets married. Arthur Crinston, Edward Norton's attorney, arrives to meet with Mr. Norton but is told to return at 11pm. When he returns, they meet for a few minutes and as he is leaving, Mr. Norton asks him to take his secretary, Donald Graves, to pick up some papers. As they drive away, Mr. Graves looks back at the house and sees someone attack Edward Norton. They return to find Edward Norton dead and Rodney Gleason, Fran's fiance, is identified as the assailant. Rodney Gleason is accused of the murder.

Hollywood producer John Addison picks up an attractive young woman hitchhiker. Far from being innocent she turns out to be a blackmailer and a witness to a murder that Addison is charged with. Perry, as usual, is hired to get to the bottom of things.

Perry has to navigate his way through a hornet's nest of murder, hit-and-run, secret marriage, and a missing witness in this episode.

Claire Olger is hitchhiking because her purse was stolen at the bus station and is picked up by Michael Greeley. He loses control of the car and has an accident due to his being intoxicated. Arriving at the scene of the accident, the police find Claire in the driver's seat. The district attorney's office questions her but do not believe her story about another driver. Her friend, Doris Stephanak, asks Perry Mason to help. When Perry is unable to contact Claire at her hotel, he goes there and finds Michael Greeley dead in her room. The police accuse Claire Olger of murder, realizing Michael Greeley fits the description of the man she claimed was driving the car and believe she had motive and opportunity.

Arthur West, a disreputable private investigator, has found J. J. Stanley in a cheap motel. He knows Mr. Stanley and his partner Ned Bain were involved in the embezzlement of the Texas National Bank. He wants to blackmail Ned Bain into giving him money to keep quiet. Harriet Bain, Ned Bain's daughter, answers the call from Arthur West and agrees to meet him. After hearing a taped conversation between J. J. Stanley and Ned Bain talking about the blackmail offer, she hires Perry Mason. Ned Bain decides to pay and meets with J. J. Stanley. The next morning J. J. Stanley is found dead in Arthur West's hotel room. Harriet Bain is accused of the murder when her fingerprints are found on the murder weapon.

When Robert Crane is charged with the murder of his sister's estranged husband Perry needs the testimony of sister Helen Reed to clear him of the charge. Unfortunately for all concerned, Helen suffers from multiple personality disorder and the second personality, Joyce Martel, is the one who is needed as the witness. Helen's psychiatrist puts her under hypnosis so Joyce can tell what she knows about the case.

Stefan Riker has come from Germany seeking the woman posing as Lisa Bannister and she believes he can cause her to be deported back to Germany. Attempting to help her stepmother, Doris Bannister pretends to be romantically interested in Stefan Riker. During the next few months Stefan Riker receives money and gifts from Doris and seems satisfied. However one night he is murdered and Doris Bannister is accused of murder because her fingerprints are found on a ladder outside of Riker's apartment.

Daniel Conway is involved in a vicious proxy war with Warner Griffith for control of an oil company. Conway's secretary, Rose Calvert, is spying for Griffith. When Rose is found dead, Conway fears he's being framed for murder and approaches Perry at a bar association dinner and asks for his aid. Perry at first believes Griffin to be the guilty party but he has an ironclad alibi. Then another witness emerges who has a photographic memory and can identify people by their shoes.

Gossip columnist Mary K. Davis is found murdered and it seems there is no shortage of suspects. There was her politician-husband to whom she refused to grant a divorce. There was her timid secretary whom she bullied. There was the secretary's boyfriend who had some secrets in his past. There was the doctor running an illegal baby-selling scheme whom Mary threatened to expose if he didn't give her a child. Leona Walsh, the doctor's nurse, ends up being charged with the crime and this time Perry has to tamper with some evidence in order to clear his client.

When wealthy Louise Gordon is poisoned to death her nurse is charged with the crime. Perry does some digging and discovers that the first wife of the victim's husband also died of poisoning. Is the husband really the culprit or could it be someone else?

Enid Griffin, the secretary of Stewart Brent, attempts to commit suicide after learning her boss has married. Arthur Binney attempts to blackmail Stewart Brent with facts about his new wife having been in jail for fraud. When Stewart Brent goes to meet Arthur Binney at a motel for the payoff, he is knocked unconscious. He awakens to find Arthur Binney dead in the next room and is put on trial for murder.

While a woman is searching the office of the South African Diamond Company, George Baxter enters to meet Walter Lumis and Duane Jefferson. He notices things in disarray and questions the woman. She makes an escape, enters Perry Mason's office, and pretends to be a typist sent by a temp agency. She leaves unannounced a short time later. Meanwhile Baxter calls for the police assuming a robbery has taken place. That evening the dead body of George Baxter is seen being thrown from a pier. Duane Jefferson is identified as the person who threw the body off the pier and is accused of the murder. However he refuses to identify the woman who could prove his innocence.

Perry receives a telephone call from George Beaumont, a man who supposedly died in a plane crash nearly three years before. In reality, Beaumont missed the plane and after hearing about the accident decided to disappear leaving wife Laura with his life insurance money. Since then, Beaumont has been cavorting with girlfriend Ruth Whittaker and living under an alias. He has grown tired of this life and wants to return home but someone cuts short his return by sticking a letter opener in his back. Ruth is then charged with the murder.