Ernesto's ""murder"" puts Miguel in control of the cartel and at odds with a pair of associates opposed to his new role. Meanwhile, Klein turns to a client (Darius McCrary) for help in getting out of the trade; and Delia steps up her plan to avenge her partner's murder. Lupita: Elpidia Carrillo. Manny: Danny Trejo. Tio Beto: Miguel Sandoval. Marlene: Sheryl Lee.

As Miguel is warned by Lupita, who forsees of a black cloud looming over his impending deal with a Thai heroin cartel; Delia is crushed after she's transferred out of El Paso. Klein's ex-wife (Sean Young) comes back with a high-priced demand that forces the doctor to take drastic action.