A friend of Ironside's turns out to be an amnesiac victim without a past. The need to discover who she really is comes to the forefront when somebody tries to kill her, and it becomes clear that the Chief's hopes for a long term relationship might not be possible with this particular girl.

A notorious jewel thief named Justin arrives in town at the same time as a shipment of famous jewels arrives for display in a local museum. Ironside must keep the thief guessing about the method of shipment so that the jewels will remain safe; but he is up against a mastermind and there is still an inside man who has to be unmasked.

Lured to a prison with a promise of information, the Chief and Mark are taken hostage by three convicts desperate to escape. Together they plot to undermine the escape attempt by turning the situation to their own advantage.

The accountant for the Police Pension Fund confesses to the murder of his secretary, but all of the evidence suggests that he could not possibly be guilty, instead pointing to another culprit and a man merely suffering from alcohol-induced hallucinations. As always, however, the Chief does not go along merely with what is 'obvious'.

Mark investigates an old case as part of his coursework research, and uncovers an apparent miscarriage of justice which implicates Ed in a fit up. The pair investigate the case to try to work out what really happened, and discover that the truth is not necessarily what it appears to be.

A gang of violent anarchists springs a protestor from prison and, when he is recaptured, try to force the police into releasing him again by kidnapping the son of a prominent lawyer. The boy, however, is in on the scheme, until he begins to realise just how far his new friends are prepared to go.

After the murder of Police Captain Belding, his daughter, a rookie cop, is anxious to prove that the allegations of corruption against him were false. She hampers the Chief's investigations and generally gets in the way, but he takes a shine to her, and has her drafted onto the team.

Ed discovers that a man sought on assault charges is Bernie Simmonds, a man who was in his class at school. Whilst pursuing the investigation he meets again with Ann Garfield, his first love; now widowed with two small children. Love, it seems, is set to blossom twice; unless Ann knows more about Bernie than she is letting on.

The Chief is sure that a man just released from prison is responsible for the murder of a policeman, but as determined as he is to prove it, the man in question is equally determined that it will never be proved. With this in mind he persuades a woman of dubious reputation to become close to Ironside, so that she can assassinate him.

The son of a judge involved in a fraud case is framed for the murder of a young actress, in the hope that this will force a lighter sentence in the fraud trial. The Chief sets out to ensure that justice can be done, whilst at the same time protecting an innocent young man from ruining a career he has not yet had a chance to embark upon.

Alone in the office, Fran Belding is attacked by an escaped convict, and helped by a mystery man who refuses to tell her his name. The next morning he is reported missing by his wife, and his disappearance seems to be connected to the case of a major drug dealer whose very existence has always been suspect.

Mark's graduation from law school coincides with the arrest of a caretaker that he has befriended. Believing the man innocent, he finds the weight of the law stacked against him, and quickly becomes disillusioned with his new career. Should he turn his back on law altogether, though, or should he just find another way to devote himself to justice?

A scientist is given a irremovable belt containing explosives, and the man responsible demands the release of three men from prison in return for the key to the device. The Chief sets out to find and trap the man before time runs out and the bomb explodes, taking an innocent person with it.

The Chief meets a man whose daughter has been murdered, and who is unable to rest until the killer is found. Moved by the old man's predicament as a victim lost in the system, Ironside decides that, since one of his statistics now has a face, he will do all that he can to see justice done.

When the team gets word of a kidnap plot, Ed goes undercover as the wheel man; but he soon finds himself battling with a fellow gang member who wants the victim dead, and is happy to kill Ed too if he gets in the way. Meanwhile the Chief struggles to gain the trust of the victim's mother, a film star whose head is being kept firmly in the clouds by her manager.

An apparently impossible robbery occurs in the safety deposit vault at a bank, and Ironside begins to unravel the details of the crime. There is only one apparent suspect, and the Chief is certain that he is not guilty; but as he investigates further, his own life may well be in danger.

The Chief is in the bank when it is robbed by a gang of three men, planning to await the arrival of a payroll delivery truck. The threesome are at odds with each other from the start, and Ironside plans to work on the antagonism between them, but they are wise to his plans and will stop at nothing to get what they want.

A sleazy magazine prints stories against the SFPD, and Ironside in particular, using the tale of a vanished actor as an example of the department's uselessness. When those involved with the story start receiving parcel bombs, it becomes clear that somebody does not want the disappearance investigated; and the Chief is all the more determined to uncover the truth.

A lawyer turns up at Ironside's door late at night, badly bruised and unable to remember what has happened to him. All that he can recall is that a man who needs rescuing is trapped in a sinking boat; but he cannot remember where the boat is, or who the man might be. The Chief begins a race against time to find the victim before it is too late.

A violent gang kills two men during a robbery, and the Chief enlists the help of a regular informant in order to capture those responsible. The informant, Baxter, is a happy-go-lucky gambler with a wife and child, who has been keeping his duel identity a secret for years. This time, however, it looks as though his secret is going to become known to everybody.

A packet of heroin goes missing, implicating Carl Reece and his partner Don Boyden in a possible cover-up. When Boyden is killed in a freak car accident, the evidence begins to point firmly at Reece, and Ironside and the team must prove his innocence before the DA decides to press charges.

An elder in the Chinese community is murdered, and a young man is held to be responsible. The Chief calls in his friends in the community to help him find the young man in question, whom he believes has been framed in order to cause a rift between young and old in China Town.

The promotion of a new Chief of Police leaves an opening for a new Chief of Detectives, and the front runner for the job is Lieutenant Amy Prentiss. Much of the force is opposed to her appointment, but she is determined to prove them wrong. With Ironside and his team alone in supporting her, she has to make her mark in a difficult case beset with problems, whilst at the same time convincing her male dominated staff to accept her as their new leader.