Jessica heads to San Francisco for the wedding of her niece, Victoria Brandon, only to learn that Victoria is having second thoughts because she suspects that her fiancé, Howard, is having an affair. Although Jessica and Victoria are relieved to learn that Howard isn't cheating but rather dressing up as a woman to perform at a nightclub, the relief is short lived when Howard is arrested for murdering his boss, Al Drake, who had been refusing to pay him. The police are convinced that Drake was shot during Freddy York's act, which doesn't leave a lot of time, but Jessica is determined to prove Howard's innocence.

Jessica suddenly must learn all about football when she inherits an interest in a professional team.

An unpublished manuscript is stolen and its author murdered during an awards convention.

When Jessica is offered an honorary degree from Crenshaw University, she has no idea she's about to become embroiled in a murder. After the boyfriend of (in)famous writer Daphne Clover is found murdered, Jessica agrees to assist the chief of police, who has never had a murder case before, find out who the killer is. She soon has more on her plate than she bargained for when first Daphne's mother confesses, then Daphne herself confesses. Jessica realises the two women are simply trying to protect each other, and begins to look at the faculty at the university.

Jessica decides to pay a visit to her long-time friend Francesca, only to learn that Francesca, who is now married to a much younger man, is convinced that she is being haunted by the ghost of her first husband, Ross. When her new husband, Scott, turns up dead, the investigation reveals that he had been poisoned, and suspicion turns to Francesca. Jessica, however, is determined to prove that her friend did not commit the crime, and begins looking into the mysterious re-appearances of her dead husband.

At the request of aunt Mildred, Jessica agrees to stop by New Orleans to check on cousin Cal while on her way to Houston. No sooner does Jessica get to New Orleans then she is tossed into a Mardi Gras party where the host ends up dead, and Cal is accused of the crime. While attempting to clear Cal's name and reputation, Jessica delves into the world of cheating poker players, cheating girlfriends and vengefilled police officers while trying to convince a local lieutenant that Cal is not capable of murder.

An adman handling the account of a fast-food chain is murdered and Jessica smells something funny.

Jessica offers to help Thomas Magnum, who has been accused of killing a hitman with an unknown target.

The crossover starts on Magnum, P.I. S07E09 Novel Connection (I).

An artist is murdered and his prized painting is missing.

Jessica goes to Quebec to testify at the trial of a friend who is accused of killing his wife and burning his house.

A colossal mix-up puts Jessica in jail as a suspect in a murder only she witnessed. British agent Hagarty returns.

The sisters used a new type of fertilizer to make their chrysanthemums best of show.

Things look bad when a married woman's keys are found by the body in a motel room and she can't explain why.

In a strange case, Jessica bumps into an old friend who is supposed to be dead. His widow insists he is dead and Jessica hires Harry McGraw to investigate.

A wealthy lumberman invites Jessica to his island retreat to discover which of his relatives is trying to kill him.

Jessica is trying to learn to invest, but this wasn't the best day for it.

Michael Hagarty is involved in a case in Sicily which has many twists and turns including the Mafia.

A young reporter is persuaded to help a typist alter the evidence and move her husband's body.

An influential father cuts no ice with Sheriff Metzger.

A woman turns up claiming that Jessica's late husband was the father of her child and he is in deep trouble involving fraud in his construction company and murder.

After Jane Dawson informs Jessica of her plans to write an unauthorized biography on her good friend Ellen Lombard, Ellen's husband Arthur comes under suspicion when Jane's sister and husband find her dead body electrocuted after a T.V. was dropped in her hot tub, and Arthur is seen leaving the house.

Evidence points to the battered wife of a powerful businessman as his killer, but Jessica establishes that there is a long list of suspects who wished him dead.

No one wants to believe that Jessica found a body in her hotel suite in London and they don't want her to believe it, either.

While Jessica is in Carmel, California, consoling a well-known playwright haunted by his wife's suicide, another family member is murdered.

Agent Michael Hagarty is arrested for the murder of his estranged daughter's crooked fiancee.