27 years after a virus wipes out most of humanity, scientists send a man back to 2015 to stop the plague from ever happening. Cole's only lead is a virologist, who knows the dangerous source of the outbreak.

Cole splinters to Tokyo, 1987 in a last chance effort to stop the Army of the 12 Monkeys.

Out of time and in need of answers, Jennifer and Deacon are sent to 1989 to steal the a sacred document. Can Railly and Cole get to the Word first before it reveals the one secret they want kept?