After Karen begins having seizures, Aaron discovers that she is terminally ill from the multiple brain metastases of a melanoma; Jeffrey resents having to perform surgery on a mobster about to enter the witness protection program; when the residents attempt to pull a practical joke on Jeffrey, they unwittingly provide comfort to a dying Karen.

Shutt has his first group counseling session with a family, and tries to help a young man whose brother commited suicide. Wilkes father comes back into his life. Hancock and McNeil try to treat a boy whom he suspects is abused, even though the child and his father deny the abuse.