An ethical debate begins after Alex suggests performing some risky surgery on conjoined twins that have been diagnosed with cancer.

Alex and Pierce are at odds about whether the hospital should provide an experimental treatment for patients with advanced-stage cancer. In other events, Max wants to change the family dynamic with Alex and Ji Sung connects with Callahan.

A patient questions Alex's ability to leave personal grief outside the OR when she performs heart surgery on the anniversary of her sister's death; Millicent dates an artist; Pierce wants to be more of a part of Alex's family.

A case brings back memories for Alex, Jesse and Millicent as they fight to save a heart transplant patient when she sustains devastating injuries in a car crash.

Alex and Ji-Sung fight to save the life of a transgender woman with breast cancer; a consultant from another hospital forces Jesse to confront her feelings for Alex.

When Alex's father needs a new kidney, an unlikely donor emerges and family secrets threaten to destroy the close relationship between father and daughter.