The ultimate consequences of domestic drug abuse become much clearer when Kilmer and the team discover a Vietnam veteran and DEA Agent who are dealing and using crystal meth from a small, local lab.

In an effort to stop an assassination attempt on a major political figure, Frankie interrogates the one man who knows the potential suspect's identity. When her detainee dies in custody, it's up to Kilmer to find the would-be murderer in order to clear Frankie's name.

Atkins is reunited with a Russian agent and an American double agent from his past when the team attempts to prevent poisoned money from reaching wide circulation.

In order to avert a deadly radioactive blast, the Threat Matrix team has to work with an unsure suspect to identify terrorists who, after plastic surgery, now have new faces.