When multiple patients throughout the hospital begin to show similar, alarming symptoms, Sharpe and Bloom scramble to figure out the root of the issue. Iggy tries to create peace for a divorced couple in a dangerous situation and Kapoor experiences a flirtatious encounter. Meanwhile, Max meets a child with a rare muscular disease and desperately tries to get him into the only clinical trial in the country that could extend his life.

New Amsterdam is still reeling from the pandemic as a plane crash lands in the East River. When investigators come to interrogate the flight crew, Iggy fights against the clock to help the pilot uncover the truth. Max tracks down scarce medication after one of his own contracts COVID.

Max is forced to face the heartbreaking consequences of one of his policies. Bloom comes to a startling realization about Iggy.

Dr Max Goodwin är lysande, charmig - och den nya medicinska chefen på Amerikas äldsta offentliga sjukhus. Medan han försöker minska på byråkratin för att ge exceptionell vård, är läkarna och personalen inte så säkra. De har hört detta tidigare, och ingen annan har levererat på dessa löften. Max tar inte ett nej och bevisar att han kommer göra allt för att blåsa nytt liv det underbemannade, underfinansierade och undervärderade sjukhuset.

When Sharpe notices the hospital's blood supply is running dangerously low, Max concocts a plan to get New Amsterdam out of trouble. Reynolds realizes he has a thing or two to learn from Bloom while making peace with his new position. Iggy helps a patient face their inner demons.

Max is on a mission to fix systemic racism at New Amsterdam. Bloom treats a patient who reminds her that things aren't as they seem. Sharpe is overwhelmed while tending to a family matter. Reynolds tries to keep his composure while treating a father and son.