When Kayla accidentally sends an e-mail flaming Mr. Dupree, she lands in detention along with JB and Jett.

Tara announces she is leaving town to take an internship at a notable animal hospital, and Jett is heartbroken and angry. Kayla struggles with the idea of just being friends with Jett, but eventually puts these feelings aside and helps Jett overcome his anger with Tara. He arrives to say goodbye just before her bus leaves. Meanwhile, Artemus is dying from the poison dart, and Silverstone can find no trace of Devon Cain. Dr. Hypnoto and the Rat arrive and reveal that not only does Cain have an antidote for the poison, but they know where is hideout is. Silverstone confronts Cain and recovers the antidote, but not without disocovering that Cains father killed his parents.