Terri has never really been able to live in the home she bought as the house was filled with clutter from her hoarding. Terri and her boyfriend Kraig have always wanted to get married but the hoarding has stood in the way. Terri spends all her time as a live-in caregiver for an elderly gentleman and has hoarded clutter in his house as well. Her entire life hangs in the balance as her relationship and her career are in jeopardy. Terri is finding the process extremely difficult and is clashing with the cleanup process. She needs to organize her house, her client's house and get her hoarding disorder under control. Will the Hoarders team of experts be able to complete the job or will Terri's temper stop the process?

Collecting thousands of discounted books over the years has damaged the family property to the point that it may collapse at any moment; now Tiffany wants to build a new home and live a better life.

As a child, Carl and his mother looked in trash cans to see what useful things they could find; now that he lives alone, Carl still spends time looking for useful things in trash cans and has literally turned his house and yard into a trash landfill.

Carmen suffered the loss of her husband, Mike. After a neck injury, Carmen lost her job as a data management specialist. Being alone at home and having no job created anxiety that triggered Carmen's hoarding disorder and online shopping. Carmen's daughter Melissa is worried that Carmen's life is spiraling out of control as she has shut out communications with much of the family. With the help of the Hoarders team, Carmen wants to clean up her home and get her hoarding disorder under control.

Kate collected items from her clients when she worked as a realtor that she would often use to stage homes that she was selling. Kate grew up with an overbearing father and a submissive mother and the recent loss of Kate's husband left her with overwhelming grief to deal with. Kate's home is now in complete chaos, and the city is issuing her daily fines under code enforcement laws. With the help of the Hoarders' crew, Kate wants to clean up her life and save her home.

Peggy's divorce in 1981 left her alone when her daughter decided to live with her father. Finding a job as a live-in caregiver required Peggie to move across the country and start over. Thrift store shopping allowed Peggie to socialize after becoming alone again when her client passed away, but it also triggered her hoarding disorder. For years Peggy desired to clean up her hoard. Now with the help of the Hoarders team, she intends to unclutter her life and get her hoarding disorder under control.

Martha deals with deception from a married man, frail health, and caring for her parent's last moments in life; not wanting to ask friends and family for help strains relations and allows the clutter in her place to spiral out of control.