When her young daughter is stricken by a mysterious malady, Ichika asks Yasuke to bring them upriver to a special doctor, but Yasuke refuses.

Back in 1581, Yasuke and Natsumaru have become trusted warriors serving Nobunaga. In the present day, the mercenaries catch up to Yasuke and attack.

Abraham sends Haruto and Nikita out to find Saki, who uses her growing powers to fight back. Under torture, Yasuke has a flashback to a betrayal.