Coulson is forced to team up with surprising allies to save the world, while the S.H.I.E.L.D. team attempts to track down and rescue him.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

The team must find a way to stop Ruby before the prophesied chain reaction that can destroy the Earth is put into motion.