A journalist's head injury results in unintelligible speech, leaving House and his team at a loss; and the heat is turned up between House and Stacy when they're out of town.

House treats a 15 year old faith healer, while Wilson feels left out when he finds out House has a weekly poker game.

House decides to awaken a comatose patient so he can question the man regarding the family history of his son, who may have a genetic condition and the father is the only living relative. Meanwhile, Wilson confronts House about the stolen prescription pad as Tritter approaches Cameron, Chase, and Foreman in an attempt to divide the team and reveal their loyalties.

The doctors try to find what's wrong with a scam artist who collapses after her brain "freezes," but the case becomes personal for Foreman.

House is secretly trying to treat a fighter pilot who is a candidate for NASA's astronaut training program. Her diagnosis will be the test to choose which ones of the 40 applicants are going to take the empty spots in his team.

House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.

A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who it was, and what they had.

In the aftermath of the bus accident, House struggles with his head injuries and short-term memory loss, and must deal with a concerned Wilson who believes his friend's health may be in danger.

While en route to his father's funeral, House must help the team with a differential diagnosis on a young Chinese girl who has collapsed under mysterious circumstances.

House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe disinhibition, which causes him to speak his mind having no control over what he says and making him just like House. Meanwhile, House suspects Wilson and Taub are keeping something from him.

House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott’s brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing. Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a particular patient.

After a wild night out, a teenage girl is brought to Princeton Plainsborough with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill. As her condition worsens, she becomes unable to distinguish fact from fiction. Meanwhile, Cuddy, Wilson and House spend a weekend away from the hospital to attend a medical conference, but things don’t go as planned when House’s private investigator, Lucas returns.

House and the team take on the case of an avid blogger admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Such openness leads the team to contemplate the value of privacy, especially after House and Wilson uncover secrets from one another 's past. Meanwhile, Chase is coaxed into testing out the dating scene.

During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.

House and Cuddy are exploring the ramifications of those feelings and attempting to make a real relationship work. Meanwhile, due to a colleague's illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital's accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.