Dr. House takes Cuddy's challenge to go off his painkillers for a week, but the effects of his withdrawal symptoms may put his patient in danger.

House's wheels start turning when a pro-cyclist admits to taking performance-enhancing drugs.

A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder.