Detective Sherlock Holmes, along with his sober companion, Dr. Joan Watson, uses his uncanny ability to read people and analyze crimes to assist the NYPD on some of their more difficult cases. In the season premiere, Holmes consults on a home invasion that resulted in murder.

Sherlock uses his powers of deduction to consult on the murder of a young man who is shot upon entering his apartment. Meanwhile, Watson has dinner with her ex-boyfriend, Ty Morstan.

Sherlock uses his trademark deductive reasoning skills to find the killer of a college professor. Meanwhile, Watson gets a call from a former lover who needs her help in disproving hit-and-run charges.

Sherlock and Joan hunt for the accomplice of a murdered blackmailer who targeted families of rape victims. Meanwhile, Sherlock resists celebrating his first year of sobriety.

Sherlock resumes his hunt for Moriarty when Sebastian Moran reveals that a man who was thought to be dead from a heart attack was actually on the list of intended victims from Moriarty.

Sherlock agrees to take a case from a man claiming to be Moriarty, hoping it will bring him closer to finding his nemesis. Meanwhile, Gregson encourages Joan to give up the dangerous line of work she has chosen and go back to being a sober companion.

As Sherlock reels at the reappearance of his former lover, Irene Adler, a series of flashbacks unravel the tumultuous events that led to his downfall into addiction. Meanwhile, he and Joan once again find themselves in the crosshairs of the enigmatic Moriarty.

As Sherlock reels at the reappearance of his former lover, Irene Adler, a series of flashbacks unravel the tumultuous events that led to his downfall into addiction. Meanwhile, he and Joan once again find themselves in the crosshairs of the enigmatic Moriarty.

When Holmes and Watson set out to track down a civil contractor who leaked classified information, their lives are disrupted when they are targeted by the group of cyber-activists protecting him. Meanwhile, Joan takes the advice of a friend and signs up for an online dating service.

When a financial consulting company CEO is poisoned to death, a woman from Sherlock's past who emerges as a possible suspect.

Holmes and Watson find themselves digging through the dark world of the mob to find a killer when they discover the body of a former assassin. Meanwhile, Watson helps a close friend track down a mystery man who swept her off her feet.

When Captain Gregson’s home is invaded, Holmes and Watson work to find the masked gunman before he strikes again. Meanwhile, Gregson gives his team some insight into his private life.

Sherlock’s brother, Mycroft, arrives in New York and enlists Holmes and Watson to help solve a case involving his former fiancée. Meanwhile, Sherlock has a difficult time accepting Mycroft and Joan’s relationship.

When a beautiful young woman is murdered, Holmes and Watson investigate her ties to a billionaire CEO. Meanwhile, Mycroft makes a case for Sherlock to move back to London.

Holmes’ latest investigation takes him inside a professional dance company when an up-and-coming ballerina is murdered. Meanwhile, Watson embarks on a solo enquiry to find a homeless veteran when his friend alleges he was abducted.