Meredith works on a patient who happens to specialize in matchmaking, and a seemingly drunk patient pushes Richard's buttons and gives him a medical mystery to solve. Meanwhile, Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming as she struggles with issues in her own personal life.

Meredith has a patient whose family is celebrating Day of the Dead, making the doctors remember loved ones they have lost. Richard shares unexpected news with Meredith about her father, Thatcher. Meanwhile, Teddy tries to tell Owen that she is pregnant but they get sidetracked, and Jo encourages Link to pursue one of the doctors.

Catherine is in Los Angeles getting the new foundation ready and summons Meredith and Koracick to visit for a highly confidential consult. Meanwhile, one of the nurses is 28 weeks pregnant and collapses at the hospital while talking to Richard.