The doctors of Grey Sloan Memorial must contend with the COVID-19 pandemic; an unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment.

Grey Sloan Memorial faces new pressures as Seattle Pres is overloaded, and Grey Sloan Memorial is now on surge capacity protocol. Meanwhile, Owen and Amelia are faced with one of the most controversial surgeries of their careers.

The Grey Sloan doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. Owen experiences PTSD after he hears the explosion, while his sister Megan enlists help from Winston and Hayes in confidence. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

The crossover starts on Station 19 S05E05 Things We Lost in the Fire (I).

The blood shortage at Grey Sloan Memorial continues. Meanwhile, Meredith makes a risky decision regarding a patient, and Owen’s actions to help his fellow veterans come to light.