The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.

Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.

As the hospital spirals closer to financial ruin, Owen must make some tough decisions, which includes foregoing an expensive surgery that could save the life of a child. Meanwhile, Alex and Jo work together to save the life of an infant, and April asks Jackson for dating advice.

A gas tanker explodes on a Seattle highway, causing multiple injuries, including paramedic Matthew. Meredith and Jo help a frantic mother whose child is suffering from a mysterious illness. Owen bonds with a young boy whose parents are in critical condition. Meanwhile true colors are revealed when Alex is forced to work with Jo's boyfriend on an ailing patient.

Upon receiving some unsettling news, Meredith and Derek take preventative steps for their children’s future; a group of Syrian doctors arrive at Grey Sloan Memorial Hospital for a crash course in basic surgical skills that they plan to apply in the field; and April decides to come clean to Matthew regarding the truth about her virginity. Meanwhile, multiple pre-op patients develop infections, causing one doctor to wonder if she is at fault.

Bailey finds herself at the center of a CDC investigation surrounding the death of several of her patients, as Jackson and the rest of the board members argue over how to address the crisis with the public. Meanwhile, Cristina teases Alex about his unspoken feelings for Jo, and Owen continues to take special care of Ethan as the condition of his parents remains uncertain.

The doctors of Grey Sloan Memorial Hospital prepare for a super storm heading towards Seattle. Owen's desire to be a parent gets stronger as he becomes closer to Ethan. One wrong move puts the lives of Meredith and her baby in jeopardy. Meanwhile, Jo looks to Alex for help in a moment of crisis, and one doctor gets the shock of her life.

Grey Sloan Memorial Hospital enters crisis mode as the storm rages, resources become scarce and patients flood in by the busload. Meanwhile, one of the doctors fights for their life.

Callie makes a decision about her relationship; the doctors receive devastating news.

A betrayal intensifies the issues between Cristina and Meredith; Matthew and April make a decision about their relationship; Bailey faces difficulties with Ben's return.

April’s sisters arrive to help celebrate April’s upcoming nuptials and quickly get on her nerves. Matthew and Jackson are forced to work together when they witness a terrible accident, Callie and Arizona work hard to reestablish their relationship and Cristina is pressured to live stream an upcoming surgery. Meanwhile, a familiar face returns to the hospital.

On the day of April's wedding, the Grey Sloan Memorial doctors are all preoccupied with their own drama. Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation. Meanwhile, Derek gets a phone call that will change his life.

A young boy is admitted to Grey Sloan Memorial and his case has a profound impact on the doctors. Meanwhile, April is faced with a surprising patient, and Jo continues to deal with her estranged husband.

An agent from ICE shows up at Grey Sloan in search of an employee who may be working in the U.S. under DACA. Alex’s patient Kimmie wants to leave the hospital to enjoy her final days, but Alex feels differently. Meanwhile, Arizona treats Matthew Taylor’s baby and April wants to do whatever she can to help.

One of Grey Sloan Memorial’s own is seriously injured, making the team reflect on what is truly important to them. Meanwhile, Nicole Herman pays a visit to Grey Sloan and talks to Arizona about an exciting opportunity.

Meredith Grey and the team of doctors at Grey Sloan Memorial are faced with life-or-death decisions on a daily basis. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.