When the producer of the reboot of a classic SF show is murdered at a Las Vegas science-fiction convention attended by both Hodges and Wendy (both, unknown to each other, fans of the original show), they find a connection with each other as the team investigates the crime.

When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.

The team investigates when a woman is attacked by a shark in the pool at a Las Vegas casino.

When shredded remains of a man are discovered, evidence leads to multiple possible suspects.