Langston is shocked when his former student is found murdered and becomes the focus of a CSI investigation into the world of Mexican wrestling.

A series of indeterminate deaths test the deductive powers of the CSI team, who fear that a public health emergency may be in the offing. Meanwhile, a friendly rivalry over who will win an upcoming bikini contest takes a deadly turn...

Catherine and Detective Vartann are thrown together in a hotel room for 24 hours as they stake out a duo making drugs in the room next door. Meanwhile, Nick and Langston work a case that involves a fetish which has become big business in Vegas.

The murder of a retired Army Ranger brings the FBI in on the case, to Russell and Catherine's initial chagrin.