The whole team investigates the crime scene of an indoor amusement park when a young girl is found dead in the bathroom. They must track down the relentless man responsible for the heinous crime quicker than usual, as everyone on location has been detained until they can be cleared. What looks to be like a regular attempted kidnapping turns out to be much more than any of the detectives had bargained for.

Horatio, Speedle and Calleigh root through the evidence in the homocide of a strange, and unorthodox college professor when they find him tied to a tree. Elsewhere, Delko and Megan investigate a car found in the water with a dead body in the trunk, and immediately suspect an insurance scam.

A dead junkie is found on a Miami street with a broken neck and a wad of cash in his hand. When the body is taken to the lab, Alexx notices that the victim's right hand is burned down to the muscle, even though it wasn't like that when he was found. It's deduced that he was exposed to radioactive material. The investigation leads Horatio to an environmental lawyer involved in radiation cases. Shortly thereafter, she learns that she is being eaten up inside by the deadly substance and has only days to live, but she doesn't know how she ingested it or who gave it to her.

The investigation into a drug heist offers brief glimpses into the private lives of the CSIs, whose nerves are on edge when they become suspects in the crime they're trying to solve. A police convoy headed across town includes an unmarked truck filled with confiscated drugs being taken to an incinerator to be destroyed. The trip ends abruptly when thieves hijack the vehicle, kill its driver and shoot Speedle, who was riding shotgun. It's hard for Horatio when the media draw comparisons to a similar case several years ago in which his brother, an undercover cop, was killed. But it's worse for his team when Internal Affairs decides that one of them tipped off the robbers about the delivery.

A man and his wife are trying to drive out of a hurricane's fury when they strike and kill a man in the blinding storm. Horatio finds that the lack of impact wounds on the victim's knees suggest that he struck the car as opposed to the car striking him. Meanwhile, in a seemingly unrelated case, Horatio finds another victim of the hurricane impaled on a fence. However, as the CSIs uncover the scattered remains of the post-storm evidence, it seems that these two cases may have a deadly connection. Meanwhile, after Calleigh witnesses a man looting a house, she realizes that she's got another case on her hands when she finds his ex-wife inside shot to death.

A diamond broker carrying two million dollars in merchandise is murdered after his car is hit by another vehicle and he gets out to confront the driver. The only witness to the crime is a developmentally challenged man who says the killer is someone named Colton. Meanwhile, outside of town, Speedle and Delko investigate the death of a teenage girl discovered at a rest stop with a broken neck. Shortly after the victim is taken from the scene, her body disappears during transport to Miami.

Josh Dalton, a hot, young reporter for the Miami Sun, witnesses the murder of his friend, a city councilman's aide, in Miami's drug district, the Golden Triangle. Josh, who was suspiciously unharmed in the attack, claims that they were only down there on a story, but Horatio believes that there's more to the situation. Later, another writer from the same paper is found shot to death inside the trunk of her car, which was reported stolen. Now, as the evidence rejects Josh's version of what happened, the CSIs find themselves entangled in the world of fast-paced journalism and learn that there is a dangerously fine line between the truth and what sells newspapers.

A security guard is found dead after shots ring out at a rap star's concert and the CSIs must investigate. Rap star 10-Large won't talk to the police regarding the murder or why someone would try to kill him. But when evidence suggests that perhaps 10-Large's bodyguard was the intended target, the CSIs must look into the dangerous world of personal security. Meanwhile, Alexx gets the shock of her life when a supposed cadaver from a recent car accident wakes up in her morgue, suffering only from hypothermia.

An 18-year-old girl is stabbed to death in a bathroom of a popular Miami nightclub. Horatio learns that the victim was an investigative aide working for Alcohol Beverage Control and was monitoring underage drinking. As Horatio interviews the club's owner, an unknown man drives by the club, sees that the police are there, and crashes his car while fleeing the scene. However, the case gets more complicated when they discover another murdered victim inside the car. DNA from the second victim's watch ultimately leads them to a day spa where the services may not be entirely legal. Meanwhile, Calleigh and Ryan work together to determine whether an insecure and underage teenager at the club that night had anything to do with the murder.

The CSIs must investigate when a pedestrian is killed after a man falls from a building and lands on him. Horatio and the team find that the victim found on the sidewalk is not the same man who fell from the building, but the unfortunate person he landed on. The CSIs discover that the fallen victim is in possession of a sex DVD involving a top Miami criminal judge and a woman with a sordid sex life. When the woman is found dead, the team must delve into the complicated personal lives of those in Miami's judicial system in order to find the killer.

When the CSIs find a woman swallowed whole and killed by a gigantic snake, they uncover a covert drug smuggling operation. Evidence leads Horatio and the team to a drug smuggling operation where large snakes are suspected of be being used to bring illegal drugs into the country to avoid detection by customs. However, when Horatio finds that Clavo Cruz, a nemesis of Horatio's who hides behind his diplomatic immunity, may be behind the operation, the team must find a legal way to put the criminal behind bars. Meanwhile, Wolfe must find the truth when two women each claim that they are the real victim of identity theft and the other is the culprit.

An IRS agent is killed while trying to repossess a delinquent taxpayer's yacht soon after the CSIs discover a second IRS agent shot to death. Now, just when everyone has a reason to detest the IRS, Horatio must find who is behind what could possibly be a series of murders right before tax day.

An axe murderer on death row is given a stay of execution just moments before it was to take place, on the grounds that there may have been tainted DNA analysis used at his trial. Now, without using any DNA evidence, the team must race against time and reexamine all of the physical evidence in the case, just as they get a call on a new double murder that looks suspiciously like the case they're working on.

Three suburban housewives on a girls' weekend in Miami are the prime suspects when the hotel's handsome pool boy is found murdered. When Horatio is tipped off that his team is facing a surprise efficiency review, he must trust Calleigh, Delko and Ryan to work together to find the killer. However, when they independently follow the evidence, each discovers that their analysis points to a different killer.

A drug lord is gunned in his Coconut Grove mansion and a suspect arrested at the scene claims he sells marijuana to Delko. Stetler, from Internal Affairs, investigates and the case quickly gets personal when Horatio gets involved. As for the shooting, the CSIs learn that two gunmen may have been involved. Also, Calleigh makes a major decision concerning her job.

Horatio hunts for the man responsible for a brutal rape on a woman years back, after new DNA testing technology finds the convicted rapist innocent.

After a group of wealthy women are robbed at a luxury day spa, evidence leads the CSIs to believe that this is a part of a much larger car chopping scam and each of these women are being targeted for a home robbery. Matters become worse when Horatio discovers that Marisol was also at the spa during robbery and he must now protect her when her life is threatened. Meanwhile, Ryan must deal with the fallout after he freezes during a shootout.

A cruise ship that is docked in Miami is the scene for a double murder. The team investigates the long list of potential suspects but soon find that the list is dramatically decreased when the CSI's find a large amount of money is missing from the victim's stateroom. Horatio and Marisol's relationship evolves.

The CSI’s investigate the murder of a male model and have to figure out the inner workings of the modeling world in order to find his killer.

Horatio has Eric rushed to the hospital and watches as the doctors try to revive him. The rest of the CSI team finds evidence that may lead them to Cruz.

After a movie star is killed at a celebrity rehab center, the CSI's investigate the secrets that the star was about to reveal and if this is what caused him to have been killed.