Sketches include Rachel Maddow Cold Open, Anne Hathaway Monologue, Message from the TSA, Miley Cyrus Show, Penelope Thanksgiving, Visiting the Queen, Weekend Update, Herb Welch, Black Friday, and Camel Tame.

Florence + The Machine perform "Shake It Off" and "No Light No Light."

Sketches include "Romney: Raw & Unleashed," "Red Flag," "Replacing Regis," "Kemper-Pedic," "Vogelchek Thanksgiving," "Mitch's Retirement Party," "A New Jack Thanksgiving," "Seducing Women Through Chess" (Digital Short), "Andre the Giant Chooses An Ice Cream Flavor," and "Blue Jean Committee."

Reese Witherspoon makes her second appearance as host alongside musical guest Florence + the Machine. Sketches include 2016 Republicans Cold Open, Mother's Day Apologies Monologue with Reese Witherspoon, Picture Perfect, High School Theatre Show and Whiskers R' We Spring Cat Giveaway.